Nerve ultrasound — a scan that uses high-frequency sound waves to create real-time images of the body’s nerves — may be used to monitor signs of polyneuropathy, or widespread damage, in people who carry disease-causing TTR mutations but have not yet developed symptoms of hereditary transthyretin amyloidosis with polyneuropathy…

Adults who carry the Val30Met, or V30M, mutation — the most common cause of early-onset hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) — often develop heart rhythm problems early on, a study shows. Although V30M carriers may be less likely to have cardiomyopathy, or heart muscle disease, those who do experience…

Hereditary diseases not only affect the body, but they also ripple through families, shaping relationships, identities, and mental health. I know this reality all too well. My late husband, Aubrey, was diagnosed in 2013 with hereditary ATTR amyloidosis, a genetic disorder caused by mutations in the TTR gene.

RNA-targeted therapies — ones that zero in on molecules acting as messengers for genetic information in cells — are safe and effective at slowing the progression of neurological symptoms and improving quality of life among people with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN). Those are the findings of a…

Polyneuropathy, or widespread nerve damage, occurs in both hereditary and wild-type transthyretin amyloidosis (ATTR), but the hereditary form, which includes familial amyloid polyneuropathy (FAP), tends to cause more severe nerve impairment. Hereditary ATTR was also more often associated with gastrointestinal symptoms and less often connected to carpal tunnel…