Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), also known as familial amyloid polyneuropathy (FAP), is a rare genetic disease characterized by damage to the peripheral nerves found outside the brain and spinal cord. It is typically…
Problems associated with nerve damage are the main symptoms of hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN). However, because the disease can affect multiple organs and systems in the body, including the heart, clinical manifestations…
Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) diagnosis typically involves identifying hATTR-PN symptoms and performing specialized testing to confirm the disease’s presence. Inherited mutations in the TTR gene cause hATTR-PN by destabilizing and changing the…
Medications, clinical monitoring, and symptom management can all play a role in hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) treatment. Also known as familial amyloid polyneuropathy, hATTR-PN is a genetic condition marked by polyneuropathy, or…
Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), also known as familial amyloid polyneuropathy (FAP), is a form of familial amyloidosis caused by mutations in the TTR gene, which contains instructions for cells to produce a…
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People carrying mutations known to cause hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) who are not yet showing symptoms may already have disease-associated toxic protein clumps in the heart, a study suggests. Greater heart abnormalities…
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An international team of experts has published new guidelines for diagnosing and treating hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) and forms of the disease that affect both the nerves and heart. The recommendations “underscore…
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Oct. 26 is World Amyloidosis Day, and advocates around the world are joining together to shine a light on transthyretin amyloid cardiomyopathy (ATTR-CM) and other forms of amyloidosis. Amyloidosis refers to a group of…
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Most people with transthyretin amyloidosis (ATTR) in China have a hereditary form of the rare disease and experience symptoms of both ATTR with polyneuropathy (ATTR-PN) — marked by nerve problems and muscle weakness —…
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As modern treatments help people with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) live longer, symptoms affecting the brain and spinal cord are becoming increasingly common over time, a new study shows. The research focused…
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People with hereditary transthyretin amyloidosis (hATTR) should be checked for polyneuropathy (damage to multiple nerves) in addition to cardiomyopathy (heart damage), a study in the U.S. suggested. While all hATTR patients in the study had…
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Onpattro (patisiran) slows neuropathy (nerve damage) progression in people with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) who respond poorly to tafamidis meglumine, a real-world study in Europe showed. After switching to Onpattro, patients…
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A newly developed questionnaire may help flag early signs of hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) in people carrying mutations in the TTR gene that are known to cause the disease, a study shows. Although…
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Early-career researchers studying transthyretin amyloidosis (ATTR), a group of conditions that includes hereditary ATTR with polyneuropathy (hATTR-PN) and ATTR cardiomyopathy (ATTR-CM), are being called to apply for one of two $100,000 research grants.
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A family history of nerve disease, carpal tunnel syndrome in both hands, and balance problems are the “clinical ‘red flags'” most strongly linked to a positive genetic test for mutations associated with hereditary transthyretin amyloidosis…