Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), also known as familial amyloid polyneuropathy (FAP), is a rare genetic disease characterized by damage to the peripheral nerves found outside the brain and spinal cord. It is typically…
Problems associated with nerve damage are the main symptoms of hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN). However, because the disease can affect multiple organs and systems in the body, including the heart, clinical manifestations…
Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) diagnosis typically involves identifying hATTR-PN symptoms and performing specialized testing to confirm the disease’s presence. Inherited mutations in the TTR gene cause hATTR-PN by destabilizing and changing the…
Medications, clinical monitoring, and symptom management can all play a role in hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) treatment. Also known as familial amyloid polyneuropathy, hATTR-PN is a genetic condition marked by polyneuropathy, or…
Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), also known as familial amyloid polyneuropathy (FAP), is a form of familial amyloidosis caused by mutations in the TTR gene, which contains instructions for cells to produce a…
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Discussion
Many adverse-event reports and safety signals linked to Amvuttra (vutrisiran) treatment for hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) in real-world databases were consistent with the therapy’s reported safety profile in clinical trials, a…
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Treatment with Wainua (eplontersen) was associated with slower disease progression and improved quality of life in both men and women with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN). That’s according to an exploratory analysis…
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Carpal tunnel syndrome (CTS) in both wrists may be a red flag of transthyretin amyloidosis (ATTR), including hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), a study showed. The researchers also identified imaging abnormalities in the…
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Amvuttra (vutrisiran) safely and effectively eases symptoms, reduces disability, and improves quality of life in East Asian adults with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), according to a subgroup analysis of the global…
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Use of the approved therapy Wainua (eplontersen) effectively slows disease progression and improves quality of life among adults with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) — characterized by damage to the peripheral nerves…
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A rare mutation in the TTR gene — mutations in which are the cause of hereditary transthyretin amyloidosis (hATTR) — resulted in early, progressive neurological symptoms that were followed by heart damage manifestations in a…
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A blood test commonly used to help diagnose Alzheimer’s disease may also identify people with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), characterized by damage to the peripheral nerves found outside the brain and spinal…
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Six months of treatment with Amvuttra (vutrisiran) appears to maintain or slightly improve clinical status and quality of life among adults with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), according to a small real-world…
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Hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) was a common clinical manifestation among people carrying a mutation in the TTR gene called p.Ala117Ser, according to a study conducted in Thailand. Similar to findings from other…
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Homes and landmarks across the U.S. and other countries will once again light up in red throughout March for Amyloidosis Awareness Month as the Amyloidosis Foundation reprises its annual “Light the Night for Amyloidosis”…